BENCE JONES PROTEIN (URINE FREE LIGHT CHAINS)
Why Get Tested?
Multiple myeloma (cancer of the plasma cells) – proteinuria due to the presence of excess proteins in blood that overflow into the urine (Bence-Jones protein) may be seen in multiple myeloma. Bence-Jones protein consists of an abnormal immunoglobulin light chain (either kappa or lambda) that is produced by monoclonal plasma cells. All immunoglobulins are composed of four protein chains, two light chains and two heavy chains. Bence-Jones protein is made of two immunoglobulin light chains and its presence in urine is often diagnostic of multiple myeloma in the context of other symptoms.